Nanocrystals for Enhancement of Oral Bioavailability of Poorly Water – Soluble Drugs

Nanocrystals for Enhancement of Oral Bioavailability of Poorly Water – Soluble Drugs

Faculty of Pharmacy, Mahidol University

Title :

Nanocrystals for Enhancement of Oral Bioavailability of Poorly Water – Soluble Drugs

Researchers :

Prof.Dr.Varaporn B. Junyaprasert
Dr.Boontida Morakul

Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied for nanocrystals production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge™, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology. For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which were discussed in this review. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals were also described.

Award Grant related to the Project : Award of “Top 10 Most Cited Articles” published in Asian Journal of Pharmaceutical Sciences during 2013-2015 at the 5th Asian Symposium on Pharmaceutical Science and Technology (ASPST 2018) & The 5th Enlarged Editorial Board Conference of Asian Journal of Pharmaceutical Science (AJPS), 9 – 10 May 2018, Hangzhou, China.

Publishing : Junyaprasert VB*, Morakul B. Nanocrystals for Enhancement of Oral Bioavailability of Poorly Water – Soluble Drugs. Asian J Pharm Sci 2015, 10: 13 – 23.

Key Contact Person :
Prof.Dr.Varaporn Junyaprasert
Faculty of Pharmacy, Mahidol University