The purpose of this study was to determine the influence of high organic substances with concentrations in fermented rice noodle (Khanomjeen) factory wastewater on the efficiency wastewater treatment of plants (Vetiveria zizanioides Nash. and Cyperus corymbosus Rottb.). Addition, The continuous flow condition and 5-days stagnation and 2-days releasing condition experiments were performed in the bath – flow wastewater treatment system. This study was divided into 2 parts namely; wastewater treatment by use of grown materials (GMs) only and wastewater treatment by use of grown materials combining with plants (GPs). The results revealed that high concentrations of organic substances (show in form of chemical oxygen demand; COD) at 3.669.70 ± 134.50 mg/L have more effect with efficiency wastewater treatment of GMs and GPs. The GMs could be reduced COD to 121.65 ± 43.45 mg/l at the 1 week-cycle (7 days). In part of GPs, Vetiveria zizanioides Nash. and Cyperus corymbosus Rottb. could be reduced COD to 140.63 ± 14.06 mg/l at the 4 week-cycles (28 days) and 128.65 ± 0.00 mg/l at the 3 week-cycles (21 days), respectively. The COD of effluent exceeded 120 mg/l which the limitation COD value of the Department of industrial works. From GPs experiment units, Vetiveria zizanioides Nash. has higher treatment efficiency than Cyperus corymbosus Rottb., which the statistically significant difference was detected with the p value < 0.05. In conclusion, plants had tolerance to high concentration of organic substances for a short duration of the experiment only. The effectiveness of wastewater treatment will decreased following the period of treatment cycles. Therefore, the results of these studies could be considered to apply for fermented rice noodle (Khanomjeen) factory wastewater treatment.