Title & Institution: Professor, Department of Microbiology and Immunology, National Cheng Kung University

Email: yslin1@mail.ncku.edu.tw

Topic in NCKU Research Week: Dengue subunit vaccines

Abstract:

The development of an effective and safe vaccine for dengue virus (DENV) infection is in urgent need. Compared to the attenuated vaccines, we consider that protein subunit vaccine might be a better vaccine candidate. NS1 has been considered as a desirable candidate for its ability to induce cytolysis of DENV-infected cells and to block NS1-mediated pathogenic effects. Currently, we are testing the protective effects contributed by the fusion proteins composing of ΔC NS1, consensus envelope protein domain III (cEDIII), and NS3 as a potential strategy for dengue vaccine design.

Personal Profile: Professor Yee-Shin Lin’s current research interests and efforts have focused on Dengue disease pathogenesis, therapeutic antibodies, and vaccine strategy as well as host-pathogen interaction in Group A Streptococcus infection.

Website link to personal research profile:  https://researchoutput.ncku.edu.tw/en/persons/yee-shin-lin