Title & Institution: 

Instructor, Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Email: jaturong.sew@mahidol.ac.th

Topic in NCKU Research Week: Dengue-specific memory CD8 T cells that have potential for protection against both dengue & Zika virus infection

Abstract:
We identified a novel dengue non-structural protein 3 epitope (NS3296-304) that induced robust proliferation of interferon gamma (IFNγ)-producing CD8 T cells in peripheral blood mononuclear cells from a Thai individual who never had dengue illness. This dengue NS3296-304 epitope is highly conserved among flaviviruses and bound common HLA-B*38 subtypes present in over 8% of the Thai population. The dengue-specific memory CD8 T cells from this person with HLA-B*38:02 proliferated and produced multiple cytokines upon stimulation in vitro with analogous NS3 epitope of Zika virus.

Personal Profile:
Memory CD8 T cell response to dengue virus infection and its cross-reactivity among flaviviruses

Website link to personal research profile: https://researchoutput.ncku.edu.tw/en/persons/guey-chuen-perng